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Everything we hold that Main Sequence published.
Every article we hold from Main Sequence.
Main Sequence announces Elaine Stead's promotion to Partner while preparing its fourth fund; CSIRO has lifted its commitment to the firm's Atmosphere pre-seed program, and two portfolio companies have reached unicorn status.
Main Sequence sets out its investment thesis for physical AI, describing portfolio companies across robotics, vision, connectivity, compute and simulation, and recalling over $100 million invested since inception.
Main Sequence explains its decision to back Facet Amtech again alongside Uniseed in a $3 million round, funding the startup's water-based ammonia catalyst work and its first pilot plant.
Also AgFunderNews·Dealroom
Main Sequence announces a follow-on seed investment in Zabidou, an industrial vision-systems startup it earlier backed at pre-seed, and recalls its previous backing of founder Cibby Pulikkaseril's LiDAR company Baraja.
Also Forbes Australia·Forbes Australia·SmartCompany·This Week in Australian Startups
Main Sequence's post sets out why the fund backed Aigentsphere, which builds governance tooling for enterprise AI agents, citing the founders' banking backgrounds and a $4 million seed raise.
Main Sequence reflects on its early backing of Deteqt through its Atmosphere platform, describing the startup's diamond-based quantum magnetic sensing chip and its case that machines need better ways to perceive their surroundings.
Main Sequence's post explains why the firm invested in Andromeda Robotics, pointing to aged-care workforce shortages, resident loneliness, and early customer enthusiasm for the Abi companion robot.
Interview with Terria founder Ana Belgun on the geospatial digital-twin company's CSIRO origins, government and infrastructure customers, 3D data challenges, and a planned Singapore hub.
Main Sequence announces backing Cortisonic, a deep-tech startup coming out of stealth with phononic chips for low-power edge AI, plus an Australian defence contract and a Lockheed Martin partnership.
Also Forbes Australia
Main Sequence explains why it backed Currus Biologics, whose BEAT platform aims to make CAR-T cell therapies effective against solid tumours, starting with mesothelin-positive cancers, as the team prepares for a clinical trial.
Main Sequence's blog post announces it led robotics software startup Breaker's pre-seed round, citing the founders' defence and robotics backgrounds and plans to expand the team and US presence.
Interview with Michele Stansfield on building Cauldron, a biomanufacturing company created to take over fermentation firm Agritechnology, her move into deep tech leadership, and plans for a purpose-built facility.
Interview with Kylee Hall, chief executive of medical device maker Cylite, on joining the Main Sequence-backed company, scaling its team, and preparing a deep-tech healthcare business for a future sale.
Main Sequence explains how it judges which AI startups build lasting value, setting out focus areas in neglected industries, efficient computing and robotics, and citing several firms from its portfolio.
Main Sequence opens a three-part series explaining its AI investment thesis, the market shifts behind it, and where it sees long-term value, citing several portfolio companies.
Main Sequence's investment post explains why the fund led geospatial platform Terria's seed round, covering its CSIRO origins, digital twin technology, and deployments for Tokyo and several Australian governments.
Main Sequence's post on leading ElectraLith's $27.5m Series A with Chevron, IP Group and other co-investors, backing its technology that turns lithium-bearing brines into battery-ready hydroxide in one step.
Also Radium Capital·Radium Capital·SmartCompany·Startup Daily·SmartCompany·RenewEconomy·RenewEconomy
Main Sequence reflects on Maxwell Plus, an early machine-vision healthcare bet it made in 2017 and later wound up, with founder and investor each sharing candid go-to-market and hiring lessons from the failure.
Also Startup Daily
Main Sequence's blog spotlights Uluu's Julia Reisser, who moved from oceanography into making biodegradable seaweed-based plastics, recalling the company's Startmate beginnings and its first product with Quiksilver.
Main Sequence describes overhauling its deal-review process after unflattering founder feedback, cutting decision times, and asks the startup community for further input.
Main Sequence unveils Atmosphere, a new program backing young Australian deep tech companies with capital and mentoring, and brings on Grace Bird to lead it as Head of Atmosphere.
Main Sequence's post explains why the fund backed quantum computing company Diraq, citing its silicon qubit approach, a chip-production deal with Global Foundries, and prior investment from Quantonation.
Also Startup Daily·@AuManufacturing·SmartCompany·Startup Daily·Startup Daily·Startup Daily
Main Sequence's essay argues science-born technology needs patient, long-horizon capital rather than quick software-style exits, citing portfolio company Samsara Eco's partnership with Lululemon as an example of deep tech's transformative payoff.
Main Sequence announces it is leading a seed extension round in Xefco, whose Ausora plasma machine replaces water-heavy textile dyeing.
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QVCDF money is going into Main Sequence to fund Queensland deep tech investing; the state government's extra $55 million takes the program to $130 million.
Deep tech venture firm Main Sequence has reached an initial A$450 million close on its third fund, pushing money under management past A$1 billion; Hostplus, Temasek and CSIRO are among the backers.
Also SmartCompany·SmartCompany·Startup Daily·SmartCompany·Startup Daily·Startup Daily·@AuManufacturing·Business News Australia·TechCrunch Venture
Main Sequence announces it led a $2.2 million seed round in Arlula, a startup building a platform for simpler access to satellite imagery and geospatial data.
Main Sequence's blog post announces soil-carbon startup Loam Bio's newly revealed $105 million Series B, led by Lower Carbon Capital and Wollemi Capital, with the fund reinvesting alongside existing backers.
Under Virescent Ventures ·leads this story in the feed
Main Sequence announces Gabrielle Munzer's promotion to its first Partner, tracing her journey from capital markets through Senior Associate and Principal roles and the signals the firm values in venture partners.
Australia's Main Sequence fund promotes Gabrielle Munzer to Partner to lead its biotech push; the article also covers her finance background, the firm's company-building model, a UNSW accelerator, and recent diverse hires.
Main Sequence announces Danielle Haj Moussa as a new part-time investment analyst, highlighting her mechatronics degree, University Medal, startup program experience and her co-founding of a tech-for-good community.
Main Sequence's blog post sets out why the fund led RIOS's US$28 million Series A, highlighting the robotics firm's automated workcells, usage-based pricing, and fit with Australia's manufacturing strategy.
Main Sequence's blog reports a $150 million commitment to CSIRO for the innovation fund it manages to speed research commercialisation, plus background on the firm's 2017 formation and its 39 deep tech investments.
Main Sequence recounts how personal relationships across CSIRO, Woolworths, ANU and prior ventures converged over years to found plastic-recycling startup Samsara Eco.
Main Sequence announces Australian Ethical has joined its second fund as a strategic backer, pairing ethical capital with deep tech investing to address challenges across health, food, space and industrial productivity.
Australia's Main Sequence has pulled in A$250 million for its second deep tech fund, with existing backers returning and a sharpened emphasis on decarbonisation investments.
Also TechCrunch Venture·TechCrunch Venture·SmartCompany·@AuManufacturing·Startup Daily·SmartCompany·TechCrunch Venture
Deals recorded from Main Sequence's coverage. A round is listed once, however many of their articles mention it.
| Company | Stage | Announced | Amount | Investors |
|---|---|---|---|---|
| Facet Amtech | Seed | 26 Aug 2026 | $3m | |
| Aigentsphere | Seed | 4 Aug 2026 | $4m | |
| Zabidou | Seed | 3 Aug 2026 | $3.5m | |
| Cortisonic | undisclosed | 2 Feb 2026 | - | |
| Currus Biologics | undisclosed | 13 Oct 2025 | - | |
| ElectraLith | Series A | 16 Jan 2025 | $27.5m | |
| Diraq | Series A | 25 Jun 2024 | $10.5m | |
| Xefco | Seed | 29 Apr 2024 | $10.5m | |
| Arlula | Seed | 22 May 2023 | $2.2m | |
| Loam Bio | Series B | 13 Feb 2023 | $105m | |
| RIOS | Series A | 23 Feb 2022 | $28m | |
| Deteqt | Accelerator | undated | - |
Companies named in Main Sequence's articles, most-covered first.
Investors named in Main Sequence's articles, most-covered first.
| Investor | What it does | Articles |
|---|---|---|
| Main Sequence Ventures | 34 | |
| CSIRO | 9 | |
| Australian Ethical | Ethical superannuation and managed funds | 2 |
| Hostplus | 2 | |
| Lockheed Martin | 2 | |
| Morgan Stanley Wealth Management | 2 | |
| Temasek | 2 | |
| Australian Department of Defence | 1 | |
| Breakthrough Victoria | 1 | |
| Chevron | 1 | |
| Daiwa Securities Group | 1 | |
| Fathom Fund | 1 | |
| Horizons Ventures | 1 | |
| In-Q-Tel | 1 | |
| IP Group Australia | Venture firm backing early-stage science and technology companies | 1 |
| LGT Crestone | 1 | |
| Lower Carbon Capital | 1 | |
| Marathon Petroleum | 1 | |
| Monash University | 1 | |
| NGS | 1 | |
| Rio Tinto | 1 | |
| The Grantham Foundation | 1 | |
| Uniseed | Venture fund backing early-stage deep tech and life science companies | 1 |
| Vista Energy | 1 | |
| Wollemi Capital | 1 |